
Delta-8 tetrahydrocannabinol, abbreviated as Delta-8 THC, is a cannabinoid that occurs naturally in the HEMP plant. Like most consumers, you probably already know that the cannabinoid offers most of the same benefits as Delta-9. But have you ever stopped to wonder how Delta-8 THC works?
Numerous studies have been done, and researchers have figured out how cannabinoids work to produce their unique effects. This guide seeks to answer the question, ‘how does Delta-8 work?
How Does Delta-8 Interact with The Endocannabinoid System?
The endocannabinoid system, or ECS, is a complex and biological cell signaling discovered in 1988 by researchers exploring tetrahydrocannabinol (THC). It comprises endocannabinoids, endocannabinoid receptors, and enzymes that work in synergy to maintain homeostasis.
When endocannabinoids bind to the receptors, they send a message that the ECS needs to kick-start a response. The ECS plays a major role in regulating vital bodily functions such as sleep, appetite, mood, body temperature, memory, pain perception, and metabolism.
Like other cannabinoids, Delta-8 is similar to your endocannabinoids, except it is produced by hemp plants. When introduced into the body, it binds to the CB1 and CB2 receptors in a similar way as your endocannabinoids. This interaction results in a range of effects, such as euphoria and relaxation. However, high doses of Delta-8 can cause anxiety and increased heart rate.
How Does Delta-8 Work?
Both Delta-8 and Delta-9 possess a double bond in their molecular structures. However, there is a slight chemical difference in the placement of the double bond. Delta-8 THC has the double bond placed on its 8th carbon atom, while Delta-9 THC has it on its 9th carbon atom.
Due to the position of its double bond, Delta-8 binds to the endocannabinoid receptors in a slightly different fashion than Delta-9. It is said to bind to the CB1 receptors in the brain with less affinity than regular THC, resulting in much less potent effects. That said, it’s important to note that studies to fully understand how Delta-8 works are still in their early stages.
What Are the Effects of Delta-8?

Research into the potential therapeutic benefits of Delta-8 is still ongoing. However, users of Delta-8 products anecdotally report relatively similar but much less potent effects to Delta-9. The cannabinoid offers a pleasurable and uplifting experience, characterized by a mellow high with a pleasant feeling of peace and calm.
Here are the most commonly reported effects of Delta-8:
- Improved focus
- Increased relaxation
- Feelings of calm and comfort
- Increased appetite
Keep in mind that the effects of Delta-8 are subjective and often vary from user to user depending on factors such as age, gender, amount consumed, and the potency of your product. Overindulgence may also result in side effects such as drowsiness and dry mouth.
Final Thoughts on How Does Delta-8 Work
Delta-8 THC works by binding to the endocannabinoid receptors in your ECS. The cannabinoid produces most of the same effects as Delta-9 THC. But because it has a lower affinity for the CB1 receptors, its effects are said to be much less potent than regular THC.
Delta-8 THC products have become incredibly popular, and their demand is skyrocketing. Even so, more rigorous research is still needed to better understand how it works, its potential benefits, and possible side effects.